Solamargine is worth being explored

Solamargine is a poisonous chemical compound that occurs in plants of the Solanaceae family, such as potatoes, tomatoes, and eggplants. It is a glycoalkaloid derived from solasodine. Solamargine can kill 100% of adult worms without incident toxicity. What’s more, it helps to heal Psoriasis and many kinds of antineoplastic effects.

To test the purity of Solamargine from Solanum nigrum , S. nigrum was extracted refluently with 80% alcohol, solamargine was purified with silica gel column chromatography and recrystallization, and then conducted its structure identification and purity checks. Screened the effect on human tumor cell groth inhibition in vitro by MTT assay, and researched on the features in mice with H22 liver cancer or Ehrlich ascites tumor of solamargine. As a result, the concent of solamargine reached 97.9%. Solamargine had significantly inhibition on 6 tumor cells in vitro, and it had significantly inhibition on mice with H22 liver cancer or ehrlich ascites tumor in the 2.4 mg x kg(-1) dose of i.v. It proved that Solamargine have the antineoplastic effect.



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