Secoisolariciresinol Diglucoside In Preventing Cardiovascular Disease

Secoisolariciresinol diglucoside(SDG) is a type of phytochemical, or plant chemical. It is found in flax, sunflower, sesame and pumpkin seeds. SDG may help boost your health. A number of studies have shown that SDG is good to human health, including prostate health, blood sugar control and cardiovascular health. As we know, cholesterol levels and blood pressure easy to cause cardiovascular disease. However, talk to your doctor before trying to prevent, treat or cure any condition with SDG.

Taking SDG may help keep your heart healthy. For one, it has cholesterol- and blood-pressure-lowering effects, according to an article published in 2010 in the “British Journal of Nutrition.” It has also been found to reduce oxidative stress on the heart, the authors discuss. Oxidation, although a natural part of cellular metabolism, leads to the production of free radicals. Free radicals are unstable compounds that can attach to and harm or destroy healthy heart cells. A specific dose is difficult suggest because the clinical study procedures have varied across studies. However, looking at the evidence as a whole, 500 mg of SDG taken for approximately 8 weeks appears to be needed to benefit heart health.

Pharmacology of Troxerutin

Troxerutin is derived from the Japanese pagoda tree and has been widely used in Western medicine since the 1960s.Troxerutin is a medication used in the treatment of varicose veins and other disorders which cause blood to pool. It is in a class of medications known as flavonoids and works by repairing damage to capillaries and making them less susceptible to subsequent damage.

It can inhibit platelet aggregation, prevent thrombosis, can cure the vascular injury induced by 5 serotonin or bradykinin, increase the capillary resistance, reduce the capillary permeability, prevent edema caused by the increasement of vascular permeability. It has the significant protective effect to acute ischemic brain injury.As the treatment of cerebral thrombosis or the sequela due from the cerebral embolism, such as the hemiplegia, aphasia and myocardial infarction syndrome, arteriosclerosis, central retinitis, phlebitis of thrombosis, varicose veins, edema caused by the vascular permeability rising.

Treatment with troxerutin is administered in a two different phases. In the first phase of treatment, medication is injected either into a vein or a muscle. Alternatively, or sometimes additionally, a patient may be given an oral dose of troxerutin for two to four weeks. Dosing is usually higher at the beginning of treatment and then lowered to maintenance levels once symptoms improve.

After initial treatment with injections or oral medication, patients may be given a topical treatment of troxerutin. The medication is usually suspended in a gel, which is spread on the affected area once or twice daily. This method of administration is quite effective in relieving the symptoms of varicose veins and in reversing the damage to the blood vessels that is caused by the condition.

What is Forskolin?

Forskolin is extracted from the Plectranthus Barbatus plant, also known as Coleus Forskohlii. Coleus Forskohlii is a plant used in alternative medicine for centuries. The plant is commonly used to support heart and respiratory health. Recently, coleus forskohlii has been associated with weight loss supplements and diet pills.

The action of forskolin (FSK), a stimulator of cAMP-dependent protein kinase (PKA), on nicotinic acetylcholine receptor- (nAChR-) channels was studied on cultured rat muscle fibres. The channel activity was estimated by determiningNp, withN, being the number of channels andp, the single channel open probability. In order to elucidate the possible role of PKA in the modulation of nAChRs, FSK (10–50 μM) was added to the bath or to the pipette filling solution in the cell-attached configuration. The first protocol used was to test for indirectly-mediated cytosolic effects, the other, for any direct effects of the drug on nAChR-channels. Using both experimental protocols, no effects on the duration of single-channel openings or conductance were observed, while channel activity was significantly reduced. In particular, FSK 10 μM) caused a reduction ofNp only when applied to the non-patch membrane. FSK at higher concentrations, produced a more marked decrease ofNp when present in the recording pipette.

Many studies have shown forskolin, as well as other actives in Coleus forskohlii, support cardiovascular health. It is most commonly used as an adjunct to a weight loss regimen rather than a primary strategy. In studies, it is usually used along with a lipolytic hormone, so it may operate synergistically with a supplement that increases lipolytic hormone levels. Forskolin has been implicated to help with reductions in blood pressure, to help treat glaucoma and perhaps even to help with colon cancer treatment.




The magic claims of Shilajit

Shilajitis a Sanskrit word meaning “conqueror of mountains and destroyer of weakness.” The sacred substance was prescribed for thousands of years for many different health problems and became a powerful tool in Ayurvedic medicine.

Many researchers claim that Shilajit exuding from the rocks of mountains is basically derived from vegetative source. Several shlokas of Susruta Samhita and Rasarangini also maintain this point of view. According to Sushruta, in the months of May-June the sap or juice of plants comes out as gummy exudation from the rocks of mountains braes due to strong heat of sun. Rasaragini, Dwarishtarang also claim that the Shilajit is an exudation of latex gum-resin etc. of plants which comes from the rocks of mountains in presence of scorching heat. But the exact source of the origin of Shilajit is still under controversy.

Shilajit is most important drug for many diseases. It increases longevity, improves memory and cognitive ability, reduces allergies and respiratory problems, reduces stress, and relieves digestive troubles. It is anti-inflammatory, antioxidant, and eliminates free radicals. The research proves that shilajit increases immunity, strength, and endurance. Many health benefits are attributed to Shilajit by regular users who live near the Himalayan Mountains. It us known as a strong kidney tonic and is said to increase the body’s core energy, responsible to sexual and spiritual power (which is why some have nicknamed it “Indian Viagra”). It is, therefore, considered an anecdote for anxiety and stress.

The healing properties of Shilajit were well-known for long. Clinical researches have been in progress and the ancient certain claims of the drug’s several properties and it is in further discovery.

What Causes Hypertension?

Hypertension, or high blood pressure, is often called a “silent disease” because you usually don’t know that you have it. Hypertension is the leading cause of stroke and a major cause of heart attack. Unfortunately, in 9 out of 10 cases, the causes of hypertension are unknown. This type of hypertension is called primary hypertension. Although not causes of hypertension, there are risk factors (such as being overweight) that increase a person’s chances of developing the condition.

When the causes of hypertension are known, the condition is called secondary hypertension. Causes of secondary hypertension include preeclampsia, kidney disease, and sleep apnea. Other causes of hypertension include certain medications, such as birth control pills.

Does Stress Cause Hypertension?

Stress and hypertension are linked in many people’s minds, but hypertension is not the same as “nervous tension.” Many people who are calm and have no stress in their lives have hypertension. While short-term stress can cause blood pressure to go up for a while, the impact of long-term stress on hypertension is not currently known.

How to diagnose Hypertension?

Your health care provider will check your blood pressure several times before diagnosing you with high blood pressure. It is normal for your blood pressure to be different depending on the time of day.

Blood pressure readings taken at home may be a better measure of your current blood pressure than those taken at your doctor’s office. Make sure you get a good quality, well-fitting home device. It should have the proper sized cuff and a digital readout.

Many medical materials are used to treat Hypertension, such as


Amlodipine Besilate





What Is an Aluminosilicate?

An aluminosilicate is any one of a vast number of naturally occurring minerals or man made compounds containing aluminum and silicate, which is made from silicon and oxygen, and possibly other elements as well, typically an alkali metal such as sodium or calcium. Many of the naturally occurring aluminosilicates are very common minerals, and while they share the same basic chemical make up, they may have differing physical properties due to the way the atoms or molecules are arranged. The same can be said of the physical properties of many of the synthetic aluminosilicate compounds as well.

The most basic forms of aluminosilicate minerals have the basic chemical formula of Al2SiO5. Several of these minerals form the basis of many types of clay, particularly the fine white clay mineral known as kaolin, and are used in ceramics manufacturing. Some rock forms of aluminosilicates with this formula are silliminate and andalusite. Other naturally occuring rock minerals in this group contain additional atoms of other elements as well, some of which are very well known, such as feldspar and topaz.

Many other more complex aluminosilicate minerals that are found in nature have somewhat different chemical formulas and other elements as part of their structure. Sodium aluminosilicate minerals are aluminosilicates that contain sodium atoms such as jadeite and albite. Others may contain potassium, calcium, sulfur, lithium, or even combinations of two or more of these or other elements in addition to aluminum and silicate. Some examples of these minerals include plagioclase, labradorite, and lazurite.

Some of the manmade aluminosilicate compounds are important to industry and have many uses. Sodium aluminosilicate is a common additive to certain foods, and acts as an anti-caking agent. Other more complex man-made sodium aluminosilicates find uses in things such as laundry detergents. Zeolites are a class of hydrated aluminosilicate minerals, many of which occur naturally. Several man-made zeolite compounds also find uses in industry.

Many crystalline forms of aluminosilicate minerals are precious and semi-precious gems. Topaz, emeralds and other beryls, tourmalines, and garnets are all aluminosilicate minerals, although each are complex aluminosilicates containing other elements besides aluminum, silicon, and oxygen. Emeralds and other beryls, for example are beryllium aluminosilicates. Garnet is a type of calcium aluminosilicate.

It is important to remember that many aluminosilicates may share identical chemical formulas but have very different physical properties. This is due to a number of factors, but is primarily a result of the way the molecules are arranged. This can lead to varying crystalline or lattice structures, each with slightly different physical properties. Such differences can also occur on a molecular level. Two minerals or compounds with identical chemical formulas can have vastly different molecular structures, resulting in divergent physical properties.


What Is the Relationship Between Diabetes and Glucose?

When people eat ordinary table sugar, called sucrose, the body digests it into fructose and glucose. Glucose is a simple sugar that the body uses to provide the cells with energy. The body normally protects itself from the damaging effects of high glucose levels by neutralizing the glucose it does not need. Insulin is the main substance used to keep blood glucose levels from becoming too high, but people who have diabetes might either have a resistance to the effects of insulin or might not produce insulin at all. This is how diabetes and glucose are related.

There are two types of diabetes, type 1 and type 2. In type 1 diabetes, the sufferer does not produce insulin at all. People who have type 2 diabetes do produce insulin, but their bodies do not respond to it as well as a healthy body would. In either type, the relationship between diabetes and glucose is direct. Untreated diabetes causes blood sugar to rise to unhealthy levels.

Diabetes and glucose levels can be controlled by diet, exercise or medication. The mode of control depends on the severity and type of the disease. People who have type 1 diabetes always have to take insulin because their bodies simply do not produce it. Control of type 2 diabetes might never involve the use of insulin treatment if the patient is compliant with prescribed medication and lifestyle modification.

There is a direct correlation between diabetes and glucose tolerance. Glucose tolerance is sometimes tested as part of the process of diabetes diagnosis. The patient drinks a solution of sugar and water right after having his or her blood sugar level tested. Blood sugar is tested two to three hours after drinking the solution. A blood sugar level of 99 to 199 might indicate prediabetes, and levels of 200 and above call for a clear diagnosis of diabetes.

Another test for diabetes involves checking the blood glucose level after the patient has been fasting for at least eight hours. If the level is high enough to arouse suspicion, the practitioner might perform the same test on another day to confirm the diagnosis. Further testing and medical history helps determine the type of diabetes, which will in turn determine the course of treatment.

Hemoglobin A1C is a test that indicates average blood glucose levels over the three months prior to taking the test. Most practitioners use hemoglobin A1C to determine how effective the current treatment is in keeping diabetes and glucose under control. Patients should take this test several times a year to be sure that the prescribed treatment is still working.



What is Hirudin?

Hirudin is a naturally occurring peptide in the salivary glands of medicinal leeches (such as Hirudo medicinalis) that has a blood anticoagulant property. It including 65 amino acid residues and three disulfide bond and it has great antithrombin activity. This is fundamental for the leeches’ alimentary habit of hematophagy, since it keeps the blood flowing after the initial phlebotomy performed by the worm on the host’s skin.

Contrary to K2-EDTA, heparin and other anticoagulants, hirudin only minimally alters blood cells and dissolved blood constituents, thus qualifying as a universal anticoagulant for diagnostic purposes. Automated complete blood counts, automated analyses of clinical chemistry analytes and immunohaematology were performed from hirudinised and routinely processed blood obtained from healthy volunteers (n=35) and hospitalised patients (n=45). Hirudin (400 ATU/ml blood) sufficiently anticoagulated blood for diagnostic purposes. The measurements of automated complete blood counts obtained from K2-EDTA-anticoagulated and hirudinised blood correlated significantly as did the measurements of 24 clinical chemistry analytes from hirudinised plasma and serum. Regression analysis revealed that the results of complete blood counts and clinical chemistry tests were predictable from the respective measurements from hirudinised blood (p=0.001). Immunohaematological tests and cross-matching from hirudinised and native blood of the same donors gave identical results. Single clotting factors, but not global coagulation analytes, could be measured from hirudinised blood. Therefore, a universal hirudin-containing blood sampling tube could be designed for automated analysis of haematological, serological and clinical chemistry analytes.

So far, Hirudin is the most potent natural inhibitor of thrombin. Unlike antithrombin III, hirudin binds to and inhibits only the activity of thrombin, with a specific activity on fibrinogen. Therefore, hirudin can be used in treatments of all kinds of thrombosis diseases.It prevents or dissolves the formation of clots and thrombi (i.e., it has a thrombolytic activity), and has therapeutic value in blood coagulation disorders, in the treatment of skin hematomas and of superficial varicose veins, either as an injectable or a topical application cream.


What is Artichoke (Cynara scolymus)?

Artichoke is a plant. The leaf, stem, and root are used to make “extracts” which contain a high concentration of certain chemicals found in the plant. These extracts are used as medicine. Artichokes rich nutrition, every 100 grams edible part contains water 80.5 g and 0.2 g of fat, protein 2.8 g and 9.9 g sugar, vitamin A160mg, vitamin C8mg, calcium and phosphorus 69 mg mg, 1.5 mg, iron, and good for people’s food thistle element, asparagine and flavonoids, etc. In all active ingredients of the artichoke, Portuguese acid (Cynarin) is the most well-known.

Artichoke is used to stimulate the flow of bile from the liver, and this is thought to help reduce the symptoms of heartburn and alcohol “hangover.” Artichoke is also used for high cholesterol, irritable bowel syndrome (IBS), kidney problems, anemia, fluid retention (edema), arthritis, bladder infections, and liver problems.

Some people use artichoke for treating snakebites, preventing gallstones, lowering blood pressure, lowering blood sugar; to increase urine flow; and as a tonic or stimulant.

In foods, artichoke leaves and extracts are used to flavor beverages. Cynarin and chlorogenic acid, which are chemicals found in artichoke, are sometimes used as sweeteners.


Carbomer is macromoleclar polymer.  Carbomer does not actually refer to one particular molecule, but is a generic term for a series of polymers primarily made from acrylic acid, which are widely used in emulsion, cream and gel. Calculations predict a planar D6h structure with bond lengths similar to the other two carbobenzenes. Its non-planar isomer is called “hexaethynyl-carbo-trannulene” – a pun on the all-cis annulenes – and resembles a cyclohexane ring. This hypothetical molecule is predicted to be more energetic by 65 kcal/mol.

It’s effective in very low concentrations – 0.1-0.5%, replacing the traditional surfactant dosage of 3-7% and it’s not restricted from HLB value and PlT. When it wet again and won’t be emulsified so it’s easy to become a waterproof emulsion without filmogen.

It is a white fluffy powder that’s used in lotions and other cosmetic formulas as a thickener, stabilizer, and emulsifier. CarboMer employs its broad technology platforms for the development of a wide spectrum of innovative products. The company manufactures research and diagnostic products, bulk intermediates, pharmaceutical actives, excipients and intermediates, cosmetic ingredients and nutraceuticals. Our products include functionalized carbohydrates, ranging from monosaccharides to polysaccharides, such as cellulosics, chitosans, cyclodextrins, dextrans, beta-glucans, heparins, hyaluronates, synthetic polymers, chiral synthons and many other products. We also offer custom organic synthesis of specialty items, such as amino acids, polypeptides, and drug delivery materials.