An Overview of Resveratrol’s Medicinal Value

1)The effect of resveratrol to the proliferation of B16 melanocyte,the activity of cellular tyrosinase and the synthesis of melanin were investigated. The results showed that resveratrol can inhibit the cellular proliferation,reduce the activity of cellular tyrosinase,and obviously decreased the content of cellular melanin compared with arbutin and ethyl vitamin C,0.5 μg/mL resveratrol solution has the same effect with 50 μg/mL arbutin and ethyl Vc. ebiochem.com

2)Resveratrol plays a role in protecting liver from damage by alcohol. Alcohol can cause liver damage in the form of steatosis or fatty liver, hepatitis, fibrosis and liver cirrhosis. In general, the amount and duration of alcohol abuse correlate with the presence and severity of liver damage, at least as regards the initial stage of fatty liver. After too much alcohol, Glutathione level will be low but after added resveratrol, this level returned soon. ebiochem.com

3) Resveratrol is believed to stimulate the SiRT1 gene; this gene is the one that kicks in when a person begins to lose weight.This same phenomenon is believed to help slow the aging process. Taking resveratrol, then, can be a way to achieve anti-aging benefits without having to go on an extreme weight reduction diet. It is not surprising that so many people are making sure to include it in their regular, balanced diet. ebiochem.com

4) Resveratrol, a nonflavonoid polyphenol naturally found in red wine and grapes, has been known to possess antioxidant, anticancer, and anti-inflammatory properties. From this study, rat primary midbrain neuron-glia cultures were used to elucidate the molecular mechanisms underlying resveratrol-mediated neuroprotection. The results clearly demonstrated that resveratrol protected DA neurons against lipopolysaccharide (LPS)-induced neurotoxicity in concentration- and time-dependent manners through the inhibition of microglial activation and the subsequent reduction of proinflammatory factor release. Mechanistically, resveratrol-mediated neuroprotection was attributed to the inhibition of NADPH oxidase. First, resveratrol reduced NADPH oxidase-mediated generation of reactive oxygen species. Second, LPS-induced translocation of NADPH oxidase cytosolic subunit p47 to the cell membrane was significantly attenuated by resveratrol. Third and most importantly, resveratrol failed to exhibit neuroprotection in cultures from NADPH oxidase-deficient mice. Furthermore, this neuroprotection was also related to an attenuation of the activation of mitogen-activated protein kinases and nuclear factor-kappaB signaling pathways in microglia. These findings suggest that resveratrol exerts neuroprotection against LPS-induced dopaminergic neurodegeneration, and NADPH oxidase may be a major player in resveratrol-mediated neuroprotection. ebiochem.com

5) Research suggests that resveratrol can help control the symptoms of asthma and improve the effectiveness of corticosteroid drug treatment. Resveratrol has been shown to reduce asthmatic symptoms by regulating immune system responses and reducing inflammation.41 In addition, recent research on patients with chronic obstructive pulmonary disease (COPD) suggests that resveratrol could also help those asthmatics who do not respond well to corticosteroids because they are insensitive or resistant to them. Studies have shown that some 50% of people with asthma have some resistance to steroidal treatment. ebiochem.com

What Are the Medical Uses of Harpagophytum?

The Harpagophytum procumbens plant belongs to the sesame family and grows in South Africa, where natives use the roots to relieve both inflammation and pain. Herbalists also use oral preparations for reducing fevers and treating kidney or liver ailments. The African people combine the roots and tubers into a topical ointment for treating boils, ulcers, and other skin lesions. Other names for the plant include devil’s claw, grapple plant, and wood spider, because of the unusual appendages of the fruit, which attach to passing animals who spread the seeds. Beginning in the 20th century, Europeans returned home with the medicinal plants and used them for appetite restoration and heartburn relief. ebiochem.com

Studies indicate Harpagophytum contains harpagoside and beta sitosterol, and research suggests that the medicinal properties of the plant achieve broader results than non-steroidal anti-inflammatory drugs. The plant extract triggers the release of cytokines, proteins that reduce inflammation. Harpagophytum also interferes with the production of cyclo-oxygnase (COX) and lipoxygenase, which contribute to inflammation and swelling. The studies suggest that these plant extracts provide relief similar to COX inhibiting medications. The British Herbal Pharmacopoeia also states that the herb can act as a diuretic, a drug that causes the elimination body fluids, and may also act as a sedative.ebiochem.com

In Europe, patients use Harpagophytum for the treatment of pain and inflammation associated with arthritis, headaches, and lower back pain. Herbal companies manufacture it in capsule and tablet form. Liquid extracts and topical ointments, containing the active ingredient, harpagoside are also available. Oral forms of the extract provide anywhere between 50 and 100 milligrams of the active ingredient. Physicians do not recommended that the herb be given to children, and health care providers advise against using it before consulting with a professional because of possible medication interactions.ebiochem.com

Taking Hapragophytum together with aspirin, warfarin or other medications that interfere with blood clotting may cause an increased risk of abnormal bleeding. Some physicians believe the preparation affects blood pressure and heart rate, requiring cautious use in patients with cardiac or circulatory problems. Some reports indicate that the plant can reduce blood sugar, which poses a threat of hypoglycemic reactions in persons using diabetic medications. The active ingredients of the plant may also interfere with the medications commonly prescribed for gastritis or ulcers, as harpagoside typically increases gastric acid secretions.ebiochem.com

Substances containing Harpagophytum may increase bile production, posing a risk for patients diagnosed with gall bladder disease. The liver breaks down and converts medications, including Harpagophytum. Taking the herb simultaneously with other medications may decrease or increase this metabolic process, affecting the effectiveness of other medications or increasing the likelihood of side effects.ebiochem.com