Ulipristal acetate is used for?

Ulipristal acetate was granted marketing authorization by the European Medicines Agency (EMA) in March 2009.

The U.S. Food and Drug Administration approved the drug for use in the United States on 13 August 2010, following the FDA advisory committee’s recommendation. Watson Pharmaceuticals announced the availability of ulipristal acetate in the United States on 1 December 2010, in retail pharmacies, clinics.

Of the 29 women studied who became pregnant despite taking ulipristal acetate, 16 had induced abortions, six had spontaneous abortions, six continued the pregnancies, and one “was lost to follow-up”.

Geting Ulipristal acetate orally as soon as possible, but no later than 120 hours (5 days) after unprotected intercourse or contraceptive failure.

Ulipristal acetate is an orally-active synthetic selective progesterone receptor modulator which acts via high-affinity binding to the human progesterone receptor. The primary mechanism of action is inhibition or delay of ovulation. Pharmacodynamic data show that even when taken immediately before ovulation is scheduled to occur, ulipristal acetate is able to postpone follicular rupture in some women.

Ulipristal acetate also has high affinity for the glucocorticoid receptor and in vivo, in animals, antiglucocorticoid effects have been observed. However, in humans, no such effect has been observed even after repeat administration at the daily dose of 10 mg. It has minimal affinity to the androgen receptor and no affinity for the human estrogen or mineralocorticoid receptors.

It is more effective at preventing pregnancy the earlier it is taken, so it is important to take it as soon as possible after unprotected sex, rather than delay it to the fifth day.

Raw material for this medicine is available on www.ebiochem.com

Pregnant women choline intake help baby health

According to a study published in the FASEB Journal, Increasing choline intake for pregnant women in late pregancy period may reduce babies’ rates of metabolism and long-term related to mental health diseases and chronic diseases such as high blood pressure.

The researchers in Cornell university and Rochester University Medical Center randomized 26 pregnancy women(the last 3 month pregancy), they separately consumed 480 mg choline and 930 mg of choline every day for 12 weeks, choline intake mainly comes from diet and supplements. The researchers tested both pregnant women’s blood sample and  placenta blood sample, Compared them to cortisol level and the genetic difference, results of the study showed that cortisol level in the placenta in high level choline intake of pregnant women group are lower and the gene which regulate of cortisol genes in placenta and baby organization are changed.

The researchers said, choline plays a very important role in fetus and infant brain development process, it can promote the baby’s brain development and improve memory. Pregnant women get more choline can help alleviate pressure and metabolism disorder, enhance its of resistance to chronic disease for babies in the future. So the researchers recommend that pregnant women can eat foods rich in choline such as eggs, lean meat, beans and broccoli.

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